Dentistry / Problems with metals
many years amalgams or " metal based "
fillings, crown and bridges made of various
metallic alloys containing metals such as
beryllium, palladium nickel ect... and titanium
implants were the norm in restoring and replacing
damaged teeth. Although not visually appealing
these metals were regarded as the best solution
for managing dental restorations. In the case of
crown and bridges they were usually layered with
a tooth coloured material to mask the metal for
aesthetic reasons. Such metallic crowns were also
placed directly over amalgam fillings, hiding
them from view but not reducing ongoing exposure
to mercury. In fact a metallic crown over amalgam
may very well induce more galvanism.
vigorous debate is still ongoing within and
outside the dental profession about possible
health risks resulting from having these various
metals in a patient's mouth for a long period of
metal-free dentistry completely side-steps the
debate by providing non metallic, visually
appealing and more structurally sound solutions
for tooth restorations. Using state of the art
synthetic, tooth coloured materials with distinct
advantages over "old style " metals.
These materials have high
strength yet can be kinder to the natural
They are attached to the
existing tooth structure by bonding, with
very high adhesion.
The materials can be
molded for a custom fit even after they
have been bonded inside the mouth.
They are tooth coloured
for a more desirable aesthetic result.
They do not corrode and do
not release metallic ions (
said at the Integrative Centre for Dental &
Natural Health, Dr. Jacques Imbeau is aware that
metal-free, as frequently advertised, does
not automatically mean " biocompatible dentistry "
because many tooth coloured dental materials can
also present their own problems including
toxicity and estrogenicity. In fact we see a
growing number of patients who had their amalgam
replaced randomly with tooth coloured materials
that were not biologically suitable for them.
the materials are carefully selected to suit the biological
and physico-mechanical needs of the individual
patient, then a metal-free approach, as
part of an integrative concept
of oral health care, can be a biomimetic
Why is it preferable to
avoid metals in the mouth?
METALS CAN INDUCE IMMUNE
EFFECTS SUCH AS CHRONIC INFLAMMATORY PROCESSES
AND AUTOIMMUNE DISEASES.
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UNDERLINED LINK BELOW TO DOWNLOAD RELEVANT STUDY
1- Immunomodulation by metals.
Lawrence DA, McCabe MJ. Jr. Int Immunopharmacol.
Occupational or environmental
exposure to metals is believed to
affect human health adversely. One mechanism
whereby metals can alter health is
through modulation of immune homeostasis.
Imbalances in immune regulation by metals can
lead to inadequate or excessive production of
inflammatory cytokines. Alternatively, metals can
lead to inappropriate activation of lymphoid
subsets involved in acquired immunity to specific
antigens. Some resultant pathologies
may include chronic inflammatory processes and
autoimmune diseases. Metals may
change the response repertoire by direct and
indirect means by influencing expression of new
antigens, new peptides, and/or antigen
presentation by modifying the antigen-presenting
complex. The differences in metal-induced immune
responses between humans and the mechanisms of
metal immunomodulationare discussed.
Metal ion induced autoimmunity. Griem P.,
Gleichmann E. Curr, Opin. Immunolol. 1995.
of mercury. Vas J. Monestrier M. Ann N Y Acad
Sci. 2008 Nov;1143:240-67.
The heavy metal mercury
is ubiquitously distributed in the environment
resulting in permanent low-level exposure in
human populations. Mercury can be encountered in
three main chemical forms (elemental, inorganic,
and organic) which can affect the immune system
in different ways. In this review, we
describe the effects of these various forms of
mercury exposure on immune cells in humans and
animals. In genetically susceptible
mice or rats, subtoxic doses of mercury induce
the production of highly specific autoantibodies
as well as a generalized activation of the immune
system. We review studies performed in this model
and discuss their implications for the role of
environmental chemicals in human autoimmunity.
Mechanisms of heavy metal induced
autoimmunity.Rowley B., Monestier M., Mol.
Immunol. 2005. May;42(7):833-8.
Chemical exposure can trigger or
accelerate the development of autoimmune
manifestations. Although elementary chemical heavy
metals are structures, they can have
profound and complex effects on the immune
system. In genetically susceptible mice or rats,
administration of subtoxic doses of mercury
induces both the production of highly specific
autoantibodies and a polyclonal activation of the
immune system. We review in this
article some of the mechanisms by which heavy
metal exposure can lead to
can a chemical element elicit complex
immunopathology? Lessons from mercury-induced
autoimmunity. Schiraldi M, Monestier M. Trends
Immunol. 2009 Oct;30(10):502-9.
autoimmune diseases develop without a manifest
cause, epidemiological studies indicate that
external factors play an important role in
triggering or aggravating autoimmune processes in
genetically predisposed individuals. Nevertheless,
most autoimmune disease-promoting environmental
agents are unknown because their relationships to
immune function are not understood. Thus, the
study of animal models of chemically-induced autoimmunity
should shed light on the pathways involved and
allow us to identify these agents. The rodent
model of heavy metal-induced autoimmunity
is one of the most intriguing experimental
systems available to address such questions.
Although the ultimate pathophysiology of this
model remains mysterious, recent studies have
started to elucidate the mechanisms by
which heavy metal exposure leads to
immune activation and loss of self-tolerance.
inflammation: Yet another example of ASIA
inflammation triggers fibromyalgia in
Orthopaedic surgery in a patient with metal
sensitivity. Adala R, Chakravarthy M, Srinivas V,
Pai S. J Cutan Aesthet Surg. 2011 Jan-Apr; 4(1):
sensitivity in patients with orthopaedic
implants: a prospective study. Frigerio, E.,
Pigatto, P. D., Guzzi, G. and Altomare, G.
(2011). Contact Dermatitis, 64:273279.
of environmental factors in autoimmune
and treatment of metal-induced side-effects.
is clinically relevant for detecting and
monitoring metal sensitivity.
to titanium: Clinical and laboratory evidence.
levels of transition metals in breast cancer
analysis of metals in dental restorations as part
of a diagnostic approach in metal
beneficial effect of amalgam replacement on
health in patients with .autoimmunity.
of dental amalgam decreases anti-TPO and anti-Tg
autoantibodies in patients
with autoimmune thyroiditis.
of MELISA for metal sensitivity testing.
17-A novel lymphocyte
transformation test (LTT-MELISA) for Lyme
reactivity is downregulated after dental metal replacement.
amalgames dentaires constituent-ils un risque
pour la sante?
of metals in autoimmunity.
lymphocytes: biomarkers of sensitivity in man.
of dental amalgam and other metal alloys
supported by antioxidant therapy
alleviates symptoms and improves quality of life
in patients with amalgam-associated
allergy is found in a majority of women with
chronic fatigue syndrome and muscle
pain and may be triggered by cigarette
smoke and dietary nickel intake.
lymphocytes: biomarkers of sensitivity in man.
lymphocytes: an indication of mercury allergy in
to inorganic mercury could be a risk factor for
& brain MRI changes in patients with
suspected metal intoxication
before and after amalgam removal.
and nickel allergy: risk factors in fatigue and
30-MELISA an in vitro
tool for the study of metal allergy.
lymphocytes: biomarkers of allergy in man.
basis for adverse reactions to radiographic
transformation test for diagnosis of
isothiazolinone allergy in man.
lymphocyte transformation test for diagnosis of
drug-induced occupational .allergy.
an aluminium-based adjuvant, indices Sjogren's
syndrome-like disorder in mice. Bagavant H,
Nadula SR, Kaplonek P, Rybakowska PD, Deshmukh
US. Clin Exp
Rheumatol. 2014 Mar-Apr;32(2):251-5. Epub
2014 Apr 9.